Cell cycle: Time to go our separate ways

Time to Go Our Separate Ways: Opposite Effects of Study Duration on Priming and Recognition Reveal Distinct Neural Substrates

Amnesic patients have difficulties recognizing when stimuli are repeated, even though their responses to stimuli can change as a function of repetition in indirect tests of memory - a pattern known as priming without recognition. Likewise, experimental manipulations can impair recognition in healthy individuals while leaving priming relatively unaffected, and priming and recognition have been a...

Wnt separate ways, met later

In This Issue In This Issue Wnt separate ways, met later embers of the Wnt family of secreted signaling proteins control a wide range of developmental and pathological processes, with each Wnt protein signaling through either the " canonical " or " noncanonical " pathway. Two papers in this issue (and a Comment on page 753) now bring these two pathways together, showing that the noncanonical ca...

Sending sisters their separate ways

S ister chromatids are often reluctant to separate during mitosis. Germann et al. show that a protein involved in DNA replication and repair helps eliminate lingering connections that can hold sister chromatids together (1). Sister chromatids tangle almost every time a cell enters mitosis. Unless the cell releases these links, the structures can break or fail to separate properly. Two kinds of ...

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Does COPI Go Both Ways?

from one Golgi complex to another under conditions that * Department of Molecular Cell Biology mirrored the conditions required for vesicle formation, Howard Hughes Medical Institute docking, and fusion. However, to many investigators University of California in the field, it remained uncertain whether the vesicles Berkeley, California 94720-3202 represented an obligatory intermediate in intra-...